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Exome Variant Analysis of Chronic Periodontitis in 2 Large Cohort Studies

Overview of attention for article published in Critical Reviews in Oral Biology & Medicine, October 2016
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Title
Exome Variant Analysis of Chronic Periodontitis in 2 Large Cohort Studies
Published in
Critical Reviews in Oral Biology & Medicine, October 2016
DOI 10.1177/0022034516665076
Pubmed ID
Authors

E. Kasbohm, B. Holtfreter, U. Völker, A. Petersmann, S. Samietz, R. Biffar, H. Völzke, P. Meisel, T. Kacprowski, G. Homuth, T. Kocher, A. Teumer

Abstract

Periodontitis is characterized by inflammation of the gingival tissue. The main risk factors are socioeconomic factors, sex, age, smoking, and diabetes, but periodontal disease has also a genetic background. Previous genome-wide association studies failed to reveal genome-wide significant associations of single common single-nucleotide polymorphisms with chronic periodontitis. Using the Illumina ExomeChip data of 6,576 participants of the German population-based cohort studies Study of Health in Pomerania (SHIP) and SHIP-Trend, the authors performed single variant and also gene-based association studies of rare and common exonic variations on different periodontal case definitions. Although our study comprised the largest sample size to date to assess genetic predisposition for chronic periodontitis, the authors found no significant association. This study emphasizes that for chronic periodontitis, large sample sizes will be necessary to find genetic associations, even when examining rare genetic variants.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 19%
Student > Ph. D. Student 5 19%
Student > Master 4 15%
Professor 2 8%
Researcher 2 8%
Other 3 12%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 12 46%
Biochemistry, Genetics and Molecular Biology 4 15%
Computer Science 2 8%
Immunology and Microbiology 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 6 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2017.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Critical Reviews in Oral Biology & Medicine
#3,626
of 3,870 outputs
Outputs of similar age
#292,211
of 332,577 outputs
Outputs of similar age from Critical Reviews in Oral Biology & Medicine
#1,194
of 1,217 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,870 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,577 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,217 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.