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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hepatitis C virus targets the interferon‐α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes
|
|---|---|
| Published in |
Febs Letters, April 2013
|
| DOI | 10.1016/j.febslet.2013.03.041 |
| Pubmed ID | |
| Authors |
Nigel J. Stevenson, Nollaig M. Bourke, Elizabeth J. Ryan, Marco Binder, Liam Fanning, James A. Johnston, John E. Hegarty, Aideen Long, Cliona O‧Farrelly |
| Abstract |
JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-α signalling. We found that STAT1 and STAT3 proteins, key components of the IFN-α signalling pathway were reduced in immune cells and hepatocytes from HCV infected patients, and upon HCV expression in Huh7 hepatocytes. However, STAT1 and STAT3 mRNA levels were normal. Mechanistic analysis revealed that in the presence of HCV, STAT3 protein was preferentially ubiquitinated, and degradation was blocked by the proteasomal inhibitor MG132. These findings show that HCV inhibits IFN-α responses in a broad spectrum of cells via proteasomal degradation of JAK/STAT pathway components. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Unknown | 49 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 26% |
| Student > Ph. D. Student | 12 | 24% |
| Student > Master | 11 | 22% |
| Researcher | 6 | 12% |
| Student > Doctoral Student | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 2 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 44% |
| Biochemistry, Genetics and Molecular Biology | 10 | 20% |
| Immunology and Microbiology | 8 | 16% |
| Chemistry | 2 | 4% |
| Medicine and Dentistry | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 4 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2019.
All research outputs
#16,063,069
of 25,394,764 outputs
Outputs from Febs Letters
#12,500
of 14,379 outputs
Outputs of similar age
#124,629
of 211,645 outputs
Outputs of similar age from Febs Letters
#38
of 56 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,379 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,645 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.