Title |
Putative effects of potentially anti-angiogenic drugs in rheumatic diseases
|
---|---|
Published in |
European Journal of Clinical Pharmacology, November 2013
|
DOI | 10.1007/s00228-013-1605-6 |
Pubmed ID | |
Authors |
Nicola Maruotti, Francesco Paolo Cantatore, Domenico Ribatti |
Abstract |
A role for angiogenesis has been described in several rheumatic diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, vasculitides, and osteoarthritis, leading to the possibility that angiogenesis inhibition may be an additional useful therapeutic arm. While the role of anti-angiogenic therapy in rheumatoid arthritis has received attention, it is conceivable that the inhibition of pathological angiogenesis may also be a useful therapeutical approach in other rheumatic diseases. Numerous compounds, such as, for example, various interleukins, antibodies directed against angiogenic factors, peptides, estrogen metabolites, disease-modifying anti-rheumatic drugs, have been found to have anti-angiogenic properties. However, additional research is needed to obtain a clear understanding of the pathogenic mechanism of angiogenesis and the potential applications of anti-angiogenic therapy in rheumatic diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 14% |
Other | 3 | 10% |
Researcher | 3 | 10% |
Student > Postgraduate | 3 | 10% |
Lecturer | 2 | 7% |
Other | 5 | 17% |
Unknown | 9 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 41% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 1 | 3% |
Unknown | 12 | 41% |