| Title |
The expansive role of oxylipins on platelet biology
|
|---|---|
| Published in |
Journal of Molecular Medicine, May 2017
|
| DOI | 10.1007/s00109-017-1542-4 |
| Pubmed ID | |
| Authors |
Jennifer Yeung, Megan Hawley, Michael Holinstat |
| Abstract |
In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear. This review highlights the burgeoning classes of oxylipins that have been found to regulate platelet function; however, their mechanism of action still remains to be elucidated. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 72 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 15% |
| Researcher | 11 | 15% |
| Student > Bachelor | 7 | 10% |
| Student > Master | 7 | 10% |
| Student > Doctoral Student | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 30 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Agricultural and Biological Sciences | 7 | 10% |
| Medicine and Dentistry | 6 | 8% |
| Chemistry | 5 | 7% |
| Nursing and Health Professions | 4 | 5% |
| Other | 8 | 11% |
| Unknown | 33 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2017.
All research outputs
#20,425,762
of 22,977,819 outputs
Outputs from Journal of Molecular Medicine
#1,342
of 1,553 outputs
Outputs of similar age
#271,484
of 311,991 outputs
Outputs of similar age from Journal of Molecular Medicine
#14
of 19 outputs
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