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Attention Score in Context
| Title |
Tunable “Nano-Shearing”: A Physical Mechanism to Displace Nonspecific Cell Adhesion During Rare Cell Detection
|
|---|---|
| Published in |
Analytical Chemistry, February 2014
|
| DOI | 10.1021/ac4032516 |
| Pubmed ID | |
| Authors |
Ramanathan Vaidyanathan, Muhammad J. A. Shiddiky, Sakandar Rauf, Eloïse Dray, Zhikai Tay, Matt Trau |
| Abstract |
We report a tunable alternating current electro-hydrodynamic (ac-EHD) force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (e.g., via the application of an ac electric field), it provides a new capability to physically displace weakly (nonspecifically) bound cellular analytes. To demonstrate the utility of the tunable nanoshearing phenomenon, we present data on purpose-built microfluidic devices that employ ac-EHD force to remove nonspecific adsorption of molecular and cellular species. Here, we show that an ac-EHD device containing asymmetric planar and microtip electrode pairs resulted in a 4-fold reduction in nonspecific adsorption of blood cells and also captured breast cancer cells in blood, with high efficiency (approximately 87%) and specificity. We therefore feel that this new capability of externally tuning and manipulating fluid flow could have wide applications as an innovative approach to enhance the specific capture of rare cells such as cancer cells in blood. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Taiwan | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 27% |
| Student > Master | 4 | 15% |
| Researcher | 3 | 12% |
| Other | 2 | 8% |
| Student > Doctoral Student | 2 | 8% |
| Other | 1 | 4% |
| Unknown | 7 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 6 | 23% |
| Agricultural and Biological Sciences | 4 | 15% |
| Engineering | 3 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 8% |
| Neuroscience | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 8 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2014.
All research outputs
#13,326,823
of 22,741,406 outputs
Outputs from Analytical Chemistry
#17,852
of 26,401 outputs
Outputs of similar age
#161,244
of 307,183 outputs
Outputs of similar age from Analytical Chemistry
#126
of 332 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26,401 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,183 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 332 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.