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Statins: protectors or pretenders in prostate cancer?

Overview of attention for article published in Trends in Endocrinology & Metabolism, January 2014
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Title
Statins: protectors or pretenders in prostate cancer?
Published in
Trends in Endocrinology & Metabolism, January 2014
DOI 10.1016/j.tem.2013.12.007
Pubmed ID
Authors

Hyeongsun Moon, Michelle M. Hill, Matthew J. Roberts, Robert A. Gardiner, Andrew J. Brown

Abstract

The role of statin therapy in prostate cancer (PCa) prevention and treatment is plagued by controversy. This critical review of published clinical series reveals several caveats in earlier studies, which reported no benefit. Recent studies that adjust for confounding factors have demonstrated statin therapy to be associated with PCa prevention and favorable clinical outcomes. Developed as inhibitors of cholesterol synthesis, the expected mechanism of statin action is systemic cholesterol reduction. By lowering circulating cholesterol, statins indirectly reduce cellular cholesterol levels in multiple cell types, impacting on membrane microdomains and steroidogenesis. Although non-cholesterol mechanisms of statin action have been proposed, they are limited by the uncertainties surrounding in vivo tissue statin concentrations.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
United States 1 2%
Romania 1 2%
Unknown 55 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Ph. D. Student 8 14%
Student > Master 7 12%
Student > Bachelor 6 10%
Other 5 9%
Other 8 14%
Unknown 11 19%
Readers by discipline Count As %
Medicine and Dentistry 18 31%
Agricultural and Biological Sciences 10 17%
Biochemistry, Genetics and Molecular Biology 7 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Computer Science 2 3%
Other 10 17%
Unknown 9 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2014.
All research outputs
#14,536,679
of 25,374,647 outputs
Outputs from Trends in Endocrinology & Metabolism
#1,098
of 1,557 outputs
Outputs of similar age
#168,940
of 320,910 outputs
Outputs of similar age from Trends in Endocrinology & Metabolism
#11
of 14 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,557 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,910 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.