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Mendeley readers
Attention Score in Context
| Title |
Caveolin-1 is required for lateral line neuromast and notochord development
|
|---|---|
| Published in |
Journal of Cell Science, June 2007
|
| DOI | 10.1242/jcs.003830 |
| Pubmed ID | |
| Authors |
Susan J. Nixon, Adrian Carter, Jeremy Wegner, Charles Ferguson, Matthias Floetenmeyer, Jamie Riches, Brian Key, Monte Westerfield, Robert G. Parton |
| Abstract |
Caveolae have been linked to diverse cellular functions and to many disease states. In this study we have used zebrafish to examine the role of caveolin-1 and caveolae during early embryonic development. During development, expression is apparent in a number of tissues including Kupffer's vesicle, tailbud, intersomite boundaries, heart, branchial arches, pronephric ducts and periderm. Particularly strong expression is observed in the sensory organs of the lateral line, the neuromasts and in the notochord where it overlaps with expression of caveolin-3. Morpholino-mediated downregulation of Cav1alpha caused a dramatic inhibition of neuromast formation. Detailed ultrastructural analysis, including electron tomography of the notochord, revealed that the central regions of the notochord has the highest density of caveolae of any embryonic tissue comparable to the highest density observed in any vertebrate tissue. In addition, Cav1alpha downregulation caused disruption of the notochord, an effect that was enhanced further by Cav3 knockdown. These results indicate an essential role for caveolin and caveolae in this vital structural and signalling component of the embryo. |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 2% |
| India | 1 | 2% |
| United States | 1 | 2% |
| Greece | 1 | 2% |
| Unknown | 62 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 24% |
| Student > Ph. D. Student | 10 | 15% |
| Student > Master | 8 | 12% |
| Student > Bachelor | 6 | 9% |
| Student > Doctoral Student | 5 | 8% |
| Other | 13 | 20% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 39% |
| Biochemistry, Genetics and Molecular Biology | 12 | 18% |
| Neuroscience | 5 | 8% |
| Medicine and Dentistry | 4 | 6% |
| Chemistry | 3 | 5% |
| Other | 8 | 12% |
| Unknown | 8 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2021.
All research outputs
#4,289,631
of 25,374,917 outputs
Outputs from Journal of Cell Science
#1,362
of 9,020 outputs
Outputs of similar age
#12,854
of 82,463 outputs
Outputs of similar age from Journal of Cell Science
#4
of 46 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,020 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,463 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.