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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hepcidin levels and gastric cancer risk in the EPIC‐EurGast study
|
|---|---|
| Published in |
International Journal of Cancer, June 2017
|
| DOI | 10.1002/ijc.30797 |
| Pubmed ID | |
| Authors |
Paula Jakszyn, Ana Fonseca-Nunes, Leila Lujan-Barroso, Núria Aranda, Mónica Tous, Victoria Arija, Amanda Cross, H B As Bueno-de-Mesquita, Elisabete Weiderpass, Tilman Kühn, Rudolf Kaaks, Klas Sjöberg, Bodil Ohlsson, Rosario Tumino, Domenico Palli, Fulvio Ricceri, Francesca Fasanelli, Vittorio Krogh, Amalia Mattiello, Mazda Jenab, Marc Gunter, Aurora Perez-Cornago, Kay-Tee Khaw, Anne Tjønneland, Anja Olsen, Kim Overvad, Antonia Trichopoulou, Eleni Peppa, Effie Vasilopoulou, Heiner Boeing, Emilio Sánchez-Cantalejo, José María Huerta, Miren Dorronsoro, Aurelio Barricarte, José Maria Quirós, Petra H Peeters, Antonio Agudo |
| Abstract |
Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5ng/l = 0.96, 95% CI = 0.93-0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a non-significant 38% (95% CI: -69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 7 | 88% |
| Unknown | 1 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 37% |
| Student > Ph. D. Student | 3 | 9% |
| Professor | 2 | 6% |
| Professor > Associate Professor | 2 | 6% |
| Other | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 31% |
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Computer Science | 2 | 6% |
| Mathematics | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 14 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#6,888,311
of 24,477,448 outputs
Outputs from International Journal of Cancer
#4,303
of 12,080 outputs
Outputs of similar age
#103,984
of 321,142 outputs
Outputs of similar age from International Journal of Cancer
#34
of 112 outputs
Altmetric has tracked 24,477,448 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 12,080 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,142 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.