Title |
Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules
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Published in |
Biology Direct, August 2009
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DOI | 10.1186/1745-6150-4-31 |
Pubmed ID | |
Authors |
Ralf Dressel, Kaomei Guan, Jessica Nolte, Leslie Elsner, Sebastian Monecke, Karim Nayernia, Gerd Hasenfuss, Wolfgang Engel |
Abstract |
Multipotent adult germ-line stem cells (maGSCs) represent a new pluripotent cell type that can be derived without genetic manipulation from spermatogonial stem cells (SSCs) present in adult testis. Similarly to induced pluripotent stem cells (iPSCs), they could provide a source of cellular grafts for new transplantation therapies of a broad variety of diseases. To test whether these stem cells can be rejected by the recipients, we have analyzed whether maGSCs and iPSCs can become targets for cytotoxic T lymphocytes (CTL) or whether they are protected, as previously proposed for embryonic stem cells (ESCs). |
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