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Metabolic Benefits of Six-month Thiamine Supplementation in Patients with and without Diabetes Mellitus Type 2

Overview of attention for article published in Clinical Medicine: Endocrinology & Diabetes, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 132)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

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1 news outlet
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7 X users
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2 patents
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1 Facebook page

Citations

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35 Dimensions

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47 Mendeley
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Title
Metabolic Benefits of Six-month Thiamine Supplementation in Patients with and without Diabetes Mellitus Type 2
Published in
Clinical Medicine: Endocrinology & Diabetes, January 2014
DOI 10.4137/cmed.s13573
Pubmed ID
Authors

Omar Al-Attas, Nasser Al-Daghri, Majed Alokail, Sherif Abd-Alrahman, Benjamin Vinodson, Shaun Sabico

Abstract

Thiamine deficiency has been documented to be prevalent in patients with diabetes mellitus, and correction of thiamine deficiency in this population may provide beneficial effects in several cardiometabolic parameters, including prevention of impending complications secondary to chronic hyperglycemia. In this interventional study, we aim to determine whether thiamine supplementation is associated with cardiometabolic improvements in patients with diabetes mellitus type 2 (DMT2). A total of 86 subjects (60 DMT2 and 26 age- and BMI-matched controls) were included and were given thiamine supplements (100 mg/day) for six months. Anthropometrics and metabolic profiles were measured routinely. Serum thiamine and its derivatives were measured using high performance liquid chromatography. In all groups, there was a significant decrease in total cholesterol after three months (p = 0.03) as well as in HDL cholesterol after six months of thiamine supplementation (p = 0.009). Significant improvements were also observed in the mean serum levels of creatinine (p = 0.001), as well as thiamine and its derivatives in both serum and urinary levels across follow-up visits (p-values 0.002 and <0.001, respectively). In the DMT2 group, improvements were observed in lipid profile (mean serum LDL and total cholesterol with p-values 0.008 and 0.006, respectively), serum thiamine (p < 0.001), TMP (p < 0.001), TDP (p < 0.001), urinary thiamine (p < 0.001) and serum creatinine (p < 0.001). Thiamine supplementation is a promising adjuvant therapy for patients with DMT2. Longer clinical trials are needed to determine its protective effect in DMT2 complications.

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X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 19%
Researcher 6 13%
Student > Bachelor 6 13%
Professor 4 9%
Student > Postgraduate 2 4%
Other 7 15%
Unknown 13 28%
Readers by discipline Count As %
Medicine and Dentistry 8 17%
Agricultural and Biological Sciences 7 15%
Nursing and Health Professions 6 13%
Biochemistry, Genetics and Molecular Biology 5 11%
Business, Management and Accounting 1 2%
Other 6 13%
Unknown 14 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#2,157,412
of 25,373,627 outputs
Outputs from Clinical Medicine: Endocrinology & Diabetes
#12
of 132 outputs
Outputs of similar age
#24,382
of 320,688 outputs
Outputs of similar age from Clinical Medicine: Endocrinology & Diabetes
#1
of 1 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,688 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them