| Title |
A pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I
|
|---|---|
| Published in |
Supportive Care in Cancer, May 2017
|
| DOI | 10.1007/s00520-017-3760-2 |
| Pubmed ID | |
| Authors |
Deirdre R. Pachman, Travis Dockter, Patricia J. Zekan, Briant Fruth, Kathryn J. Ruddy, Lauren E. Ta, Jacqueline M. Lafky, Todor Dentchev, Nguyet Anh Le-Lindqwister, William M. Sikov, Nathan Staff, Andreas S. Beutler, Charles L. Loprinzi |
| Abstract |
Paclitaxel is associated with both an acute pain syndrome (P-APS) and chronic chemotherapy-induced peripheral neuropathy (CIPN). Given that extensive animal data suggest that minocycline may prevent chemotherapy-induced neurotoxicity, the purpose of this pilot study was to investigate the efficacy of minocycline for the prevention of CIPN and the P-APS. Patients with breast cancer were enrolled prior to initiating neoadjuvant or adjuvant weekly paclitaxel for 12 weeks and were randomized to receive minocycline 200 mg on day 1 followed by 100 mg twice daily or a matching placebo. Patients completed (1) an acute pain syndrome questionnaire daily during chemotherapy to measure P-APS and (2) the EORTC QLQ-CIPN20 questionnaire at baseline, prior to each dose of paclitaxel, and monthly for 6 months post treatment, to measure CIPN. Forty-seven patients were randomized. There were no remarkable differences noted between the minocycline and placebo groups for the overall sensory neuropathy score of the EORTC QLQ-CIPN20 or its individual components, which evaluate tingling, numbness and shooting/burning pain in hands and feet. However, patients taking minocycline had a significant reduction in the daily average pain score attributed to P-APS (p = 0.02). Not only were no increased toxicities reported with minocycline, but there was a significant reduction in fatigue (p = 0.02). Results of this pilot study do not support the use of minocycline to prevent CIPN, but suggest that it may reduce P-APS and decrease fatigue; further study of the impact of this agent on those endpoints may be warranted. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 16% |
| Student > Ph. D. Student | 10 | 12% |
| Researcher | 9 | 11% |
| Student > Doctoral Student | 6 | 7% |
| Student > Bachelor | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 27 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 24% |
| Nursing and Health Professions | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Neuroscience | 3 | 4% |
| Psychology | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 37 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2017.
All research outputs
#20,425,762
of 22,977,819 outputs
Outputs from Supportive Care in Cancer
#4,065
of 4,635 outputs
Outputs of similar age
#273,013
of 313,714 outputs
Outputs of similar age from Supportive Care in Cancer
#64
of 78 outputs
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