| Title |
Arsenicosis, possibly from contaminated groundwater, associated with noncirrhotic intrahepatic portal hypertension
|
|---|---|
| Published in |
Indian Journal of Gastroenterology, May 2016
|
| DOI | 10.1007/s12664-016-0660-1 |
| Pubmed ID | |
| Authors |
Ashish Goel, Pamela Christudoss, Renu George, Banumathi Ramakrishna, G. Jayakumar Amirtharaj, Shyamkumar N. Keshava, Anup Ramachandran, K. A. Balasubramanian, Ian Mackie, Jude J. Fleming, Elwyn Elias, Chundamannil E. Eapen |
| Abstract |
Idiopathic noncirrhotic intrahepatic portal hypertension (NCIPH), a chronic microangiopathy of the liver caused by arsenicosis from use of contaminated groundwater, was reported from Asia. This study aimed to see, if in the twenty-first century, arsenicosis was present in NCIPH patients at our hospital and, if present, to look for groundwater contamination by arsenic in their residential locality. Twenty-seven liver biopsy proven NCIPH patients, 25 portal hypertensive controls with hepatitis B or C related cirrhosis and 25 healthy controls, matched for residential locality, were studied. Eighty-four percent to 96 % of study subjects belonged to middle or lower socioeconomic category. Arsenicosis was looked for by estimation of arsenic levels in finger/toe nails and by skin examination. Arsenic levels in nails and in ground water (in NCIPH patients with arsenicosis) was estimated by mass spectrometry. Nail arsenic levels were raised in five (10 %) portal hypertensive study subjects [two NCIPH patients (both had skin arsenicosis) and three portal hypertensive controls]. All of these five patients were residents of West Bengal or Bangladesh. Skin arsenicosis was noted in three NCIPH patients (11 %) compared to none of disease/healthy controls. Ground water from residential locality of one NCIPH patient with arsenicosis (from Bangladesh) showed extremely high level of arsenic (79.5 μg/L). Arsenicosis and microangiopathy of liver, possibly caused by environmental contamination continues in parts of Asia. Further studies are needed to understand the mechanisms of such 'poverty-linked thrombophilia'. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 21% |
| Other | 3 | 10% |
| Student > Master | 3 | 10% |
| Student > Postgraduate | 3 | 10% |
| Researcher | 3 | 10% |
| Other | 4 | 14% |
| Unknown | 7 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 24% |
| Environmental Science | 3 | 10% |
| Economics, Econometrics and Finance | 2 | 7% |
| Nursing and Health Professions | 2 | 7% |
| Psychology | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 13 | 45% |
Attention Score in Context
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#20,425,762
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Outputs from Indian Journal of Gastroenterology
#279
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#290,210
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Outputs of similar age from Indian Journal of Gastroenterology
#3
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