Title |
Reassortment patterns of avian influenza virus internal segments among different subtypes
|
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Published in |
BMC Ecology and Evolution, January 2014
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DOI | 10.1186/1471-2148-14-16 |
Pubmed ID | |
Authors |
Lu Lu, Samantha J Lycett, Andrew J Leigh Brown |
Abstract |
The segmented RNA genome of avian Influenza viruses (AIV) allows genetic reassortment between co-infecting viruses, providing an evolutionary pathway to generate genetic innovation. The genetic diversity (16 haemagglutinin and 9 neuraminidase subtypes) of AIV indicates an extensive reservoir of influenza viruses exists in bird populations, but how frequently subtypes reassort with each other is still unknown. Here we quantify the reassortment patterns among subtypes in the Eurasian avian viral pool by reconstructing the ancestral states of the subtypes as discrete states on time-scaled phylogenies with respect to the internal protein coding segments. We further analyzed how host species, the inferred evolutionary rates and the dN/dS ratio varied among segments and between discrete subtypes, and whether these factors may be associated with inter-subtype reassortment rate. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 57% |
Canada | 1 | 14% |
United States | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Switzerland | 1 | <1% |
Germany | 1 | <1% |
Japan | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 98 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 28% |
Researcher | 23 | 22% |
Student > Master | 15 | 14% |
Student > Bachelor | 9 | 9% |
Student > Doctoral Student | 6 | 6% |
Other | 10 | 10% |
Unknown | 12 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 37 | 36% |
Immunology and Microbiology | 13 | 13% |
Biochemistry, Genetics and Molecular Biology | 12 | 12% |
Veterinary Science and Veterinary Medicine | 11 | 11% |
Medicine and Dentistry | 7 | 7% |
Other | 12 | 12% |
Unknown | 12 | 12% |