Title |
Telomeres and human disease: ageing, cancer and beyond
|
---|---|
Published in |
Nature Reviews Genetics, August 2005
|
DOI | 10.1038/nrg1656 |
Pubmed ID | |
Authors |
Maria A. Blasco |
Abstract |
Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which can compromise cell viability, whereas tumour cells can prevent telomere loss by aberrantly upregulating telomerase. Altered functioning of both telomerase and telomere-interacting proteins is present in some human premature ageing syndromes and in cancer, and recent findings indicate that alterations that affect telomeres at the level of chromatin structure might also have a role in human disease. These findings have inspired a number of potential therapeutic strategies that are based on telomerase and telomeres. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | 1% |
France | 6 | <1% |
United Kingdom | 5 | <1% |
Canada | 3 | <1% |
Germany | 3 | <1% |
India | 3 | <1% |
Netherlands | 2 | <1% |
Finland | 2 | <1% |
Portugal | 2 | <1% |
Other | 11 | <1% |
Unknown | 1367 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 269 | 19% |
Student > Bachelor | 226 | 16% |
Student > Master | 203 | 14% |
Researcher | 165 | 12% |
Student > Doctoral Student | 88 | 6% |
Other | 184 | 13% |
Unknown | 284 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 403 | 28% |
Biochemistry, Genetics and Molecular Biology | 346 | 24% |
Medicine and Dentistry | 148 | 10% |
Chemistry | 55 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 29 | 2% |
Other | 133 | 9% |
Unknown | 305 | 21% |