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Mendeley readers
Attention Score in Context
| Title |
Telomerase deficiency impairs glucose metabolism and insulin secretion
|
|---|---|
| Published in |
Aging, September 2010
|
| DOI | 10.18632/aging.100200 |
| Pubmed ID | |
| Authors |
Doreen Kuhlow, Simone Florian, Guido von Figura, Sandra Weimer, Nadja Schulz, Klaus J. Petzke, Kim Zarse, Andreas F.H Pfeiffer, K. Lenhard Rudolph, Michael Ristow |
| Abstract |
Reduced telomere length and impaired telomerase activity have been linked to several diseases associated with senescence and aging. However, a causal link to metabolic disorders and in particular diabetes mellitus is pending. We here show that young adult mice which are deficient for the Terc subunit of telomerase exhibit impaired glucose tolerance. This is caused by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets, while body fat content, energy expenditure and insulin sensitivity were found to be unaltered. The impaired secretion capacity for insulin is due to reduced islet size which is linked to an impaired replication capacity of insulin-producing beta-cells in Terc-deficient mice. Taken together, telomerase deficiency and hence short telomeres impair replicative capacity of pancreatic beta-cells to cause impaired insulin secretion and glucose intolerance, mechanistically defining diabetes mellitus as an aging-associated disorder. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 78 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 28% |
| Researcher | 15 | 19% |
| Student > Master | 10 | 13% |
| Other | 4 | 5% |
| Student > Bachelor | 4 | 5% |
| Other | 14 | 18% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 30% |
| Agricultural and Biological Sciences | 21 | 26% |
| Biochemistry, Genetics and Molecular Biology | 15 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Unspecified | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2021.
All research outputs
#2,388,380
of 24,682,395 outputs
Outputs from Aging
#597
of 3,953 outputs
Outputs of similar age
#8,927
of 100,270 outputs
Outputs of similar age from Aging
#1
of 12 outputs
Altmetric has tracked 24,682,395 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,953 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,270 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.