Title |
Telomerase deficiency impairs glucose metabolism and insulin secretion
|
---|---|
Published in |
Aging, September 2010
|
DOI | 10.18632/aging.100200 |
Pubmed ID | |
Authors |
Doreen Kuhlow, Simone Florian, Guido von Figura, Sandra Weimer, Nadja Schulz, Klaus J. Petzke, Kim Zarse, Andreas F.H Pfeiffer, K. Lenhard Rudolph, Michael Ristow |
Abstract |
Reduced telomere length and impaired telomerase activity have been linked to several diseases associated with senescence and aging. However, a causal link to metabolic disorders and in particular diabetes mellitus is pending. We here show that young adult mice which are deficient for the Terc subunit of telomerase exhibit impaired glucose tolerance. This is caused by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets, while body fat content, energy expenditure and insulin sensitivity were found to be unaltered. The impaired secretion capacity for insulin is due to reduced islet size which is linked to an impaired replication capacity of insulin-producing beta-cells in Terc-deficient mice. Taken together, telomerase deficiency and hence short telomeres impair replicative capacity of pancreatic beta-cells to cause impaired insulin secretion and glucose intolerance, mechanistically defining diabetes mellitus as an aging-associated disorder. |
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Geographical breakdown
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United Kingdom | 1 | 1% |
Germany | 1 | 1% |
Unknown | 78 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 22 | 28% |
Researcher | 15 | 19% |
Student > Master | 10 | 13% |
Other | 4 | 5% |
Student > Bachelor | 4 | 5% |
Other | 14 | 18% |
Unknown | 11 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 30% |
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Biochemistry, Genetics and Molecular Biology | 15 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Unspecified | 1 | 1% |
Other | 4 | 5% |
Unknown | 13 | 16% |