| Title |
High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate
|
|---|---|
| Published in |
Cancer Chemotherapy and Pharmacology, January 2014
|
| DOI | 10.1007/s00280-014-2386-z |
| Pubmed ID | |
| Authors |
Bradley S. Hanberry, Ryan Berger, Jason A. Zastre |
| Abstract |
The dichotomous effect of thiamine supplementation on cancer cell growth is characterized by growth stimulation at low doses and growth suppression at high doses. Unfortunately, how thiamine reduces cancer cell proliferation is currently unknown. Recent focuses on metabolic targets for cancer therapy have exploited the altered regulation of the thiamine-dependent enzyme pyruvate dehydrogenase (PDH). Cancer cells inactivate PDH through phosphorylation by overexpression of pyruvate dehydrogenase kinases (PDKs). Inhibition of PDKs by dichloracetate (DCA) exhibits a growth suppressive effect in many cancers. Recently, it has been shown that the thiamine coenzyme, thiamine pyrophosphate reduces PDK-mediated phosphorylation of PDH. Therefore, the objective of this study was to determine whether high-dose thiamine supplementation reduces cell proliferation through a DCA-like mechanism. |
X Demographics
The data shown below were collected from the profiles of 240 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 33 | 14% |
| United Kingdom | 10 | 4% |
| Canada | 8 | 3% |
| Spain | 5 | 2% |
| Australia | 3 | 1% |
| New Zealand | 3 | 1% |
| Brazil | 2 | <1% |
| Portugal | 1 | <1% |
| Zimbabwe | 1 | <1% |
| Other | 8 | 3% |
| Unknown | 166 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 216 | 90% |
| Practitioners (doctors, other healthcare professionals) | 12 | 5% |
| Scientists | 7 | 3% |
| Science communicators (journalists, bloggers, editors) | 4 | 2% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 17% |
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 5 | 11% |
| Other | 5 | 11% |
| Student > Master | 4 | 9% |
| Other | 6 | 13% |
| Unknown | 11 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 28% |
| Agricultural and Biological Sciences | 9 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Nursing and Health Professions | 1 | 2% |
| Philosophy | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 11 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 161. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2024.
All research outputs
#257,933
of 25,738,558 outputs
Outputs from Cancer Chemotherapy and Pharmacology
#4
of 2,573 outputs
Outputs of similar age
#2,361
of 322,589 outputs
Outputs of similar age from Cancer Chemotherapy and Pharmacology
#1
of 23 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,573 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.