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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
|
|---|---|
| Published in |
Clinical Materials, January 2014
|
| DOI | 10.1016/j.biomaterials.2013.12.095 |
| Pubmed ID | |
| Authors |
Li Li, Wenyi Gu, Jiezhong Chen, Weiyu Chen, Zhi P. Xu |
| Abstract |
In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Saudi Arabia | 1 | <1% |
| Unknown | 152 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 22% |
| Student > Master | 22 | 14% |
| Researcher | 20 | 13% |
| Student > Bachelor | 12 | 8% |
| Other | 6 | 4% |
| Other | 23 | 15% |
| Unknown | 38 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 30 | 19% |
| Materials Science | 15 | 10% |
| Agricultural and Biological Sciences | 13 | 8% |
| Engineering | 13 | 8% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Other | 21 | 14% |
| Unknown | 55 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2014.
All research outputs
#20,674,485
of 25,394,764 outputs
Outputs from Clinical Materials
#9,625
of 10,758 outputs
Outputs of similar age
#243,652
of 321,308 outputs
Outputs of similar age from Clinical Materials
#129
of 149 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,758 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,308 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.