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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
|
|---|---|
| Published in |
Nature Genetics, January 2014
|
| DOI | 10.1038/ng.2882 |
| Pubmed ID | |
| Authors |
Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Patrick Sulem, Hannes Helgason, Niels Grarup, Asgeir Sigurdsson, Hafdis T Helgadottir, Hrefna Johannsdottir, Olafur T Magnusson, Sigurjon A Gudjonsson, Johanne M Justesen, Marie N Harder, Marit E Jørgensen, Cramer Christensen, Ivan Brandslund, Annelli Sandbæk, Torsten Lauritzen, Henrik Vestergaard, Allan Linneberg, Torben Jørgensen, Torben Hansen, Maryam S Daneshpour, Mohammad-Sadegh Fallah, Astradur B Hreidarsson, Gunnar Sigurdsson, Fereidoun Azizi, Rafn Benediktsson, Gisli Masson, Agnar Helgason, Augustine Kong, Daniel F Gudbjartsson, Oluf Pedersen, Unnur Thorsteinsdottir, Kari Stefansson |
| Abstract |
Through whole-genome sequencing of 2,630 Icelanders and imputation into 11,114 Icelandic cases and 267,140 controls followed by testing in Danish and Iranian samples, we discovered 4 previously unreported variants affecting risk of type 2 diabetes (T2D). A low-frequency (1.47%) variant in intron 1 of CCND2, rs76895963[G], reduces risk of T2D by half (odds ratio (OR) = 0.53, P = 5.0 × 10(-21)) and is correlated with increased CCND2 expression. Notably, this variant is also associated with both greater height and higher body mass index (1.17 cm per allele, P = 5.5 × 10(-12) and 0.56 kg/m(2) per allele, P = 6.5 × 10(-7), respectively). In addition, two missense variants in PAM, encoding p.Asp563Gly (frequency of 4.98%) and p.Ser539Trp (frequency of 0.65%), confer moderately higher risk of T2D (OR = 1.23, P = 3.9 × 10(-10) and OR = 1.47, P = 1.7 × 10(-5), respectively), and a rare (0.20%) frameshift variant in PDX1, encoding p.Gly218Alafs*12, associates with high risk of T2D (OR = 2.27, P = 7.3 × 10(-7)). |
X Demographics
The data shown below were collected from the profiles of 68 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 23 | 34% |
| United Kingdom | 9 | 13% |
| Ireland | 3 | 4% |
| Spain | 2 | 3% |
| Denmark | 1 | 1% |
| Australia | 1 | 1% |
| Georgia | 1 | 1% |
| Mexico | 1 | 1% |
| Belgium | 1 | 1% |
| Other | 8 | 12% |
| Unknown | 18 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 39 | 57% |
| Scientists | 25 | 37% |
| Practitioners (doctors, other healthcare professionals) | 4 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 279 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| Spain | 2 | <1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| South Africa | 1 | <1% |
| India | 1 | <1% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Other | 3 | 1% |
| Unknown | 263 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 74 | 27% |
| Student > Ph. D. Student | 70 | 25% |
| Student > Master | 27 | 10% |
| Student > Bachelor | 26 | 9% |
| Professor > Associate Professor | 17 | 6% |
| Other | 41 | 15% |
| Unknown | 24 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 105 | 38% |
| Biochemistry, Genetics and Molecular Biology | 64 | 23% |
| Medicine and Dentistry | 42 | 15% |
| Arts and Humanities | 5 | 2% |
| Computer Science | 4 | 1% |
| Other | 27 | 10% |
| Unknown | 32 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2021.
All research outputs
#578,536
of 25,837,817 outputs
Outputs from Nature Genetics
#1,132
of 7,639 outputs
Outputs of similar age
#5,789
of 325,849 outputs
Outputs of similar age from Nature Genetics
#14
of 61 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,849 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.