| Title |
Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses
|
|---|---|
| Published in |
Retrovirology, November 2011
|
| DOI | 10.1186/1742-4690-8-90 |
| Pubmed ID | |
| Authors |
Ravi P Subramanian, Julia H Wildschutte, Crystal Russo, John M Coffin |
| Abstract |
Integration of retroviral DNA into a germ cell may lead to a provirus that is transmitted vertically to that host's offspring as an endogenous retrovirus (ERV). In humans, ERVs (HERVs) comprise about 8% of the genome, the vast majority of which are truncated and/or highly mutated and no longer encode functional genes. The most recently active retroviruses that integrated into the human germ line are members of the Betaretrovirus-like HERV-K (HML-2) group, many of which contain intact open reading frames (ORFs) in some or all genes, sometimes encoding functional proteins that are expressed in various tissues. Interestingly, this expression is upregulated in many tumors ranging from breast and ovarian tissues to lymphomas and melanomas, as well as schizophrenia, rheumatoid arthritis, and other disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Unknown | 325 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 70 | 21% |
| Researcher | 49 | 15% |
| Student > Bachelor | 43 | 13% |
| Student > Master | 39 | 12% |
| Student > Doctoral Student | 19 | 6% |
| Other | 43 | 13% |
| Unknown | 70 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 31% |
| Biochemistry, Genetics and Molecular Biology | 79 | 24% |
| Medicine and Dentistry | 26 | 8% |
| Immunology and Microbiology | 24 | 7% |
| Computer Science | 11 | 3% |
| Other | 20 | 6% |
| Unknown | 71 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 322. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#103,826
of 25,391,066 outputs
Outputs from Retrovirology
#2
of 1,240 outputs
Outputs of similar age
#327
of 153,260 outputs
Outputs of similar age from Retrovirology
#1
of 29 outputs
Altmetric has tracked 25,391,066 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,240 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,260 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.