| Title |
RBM20, a potential target for treatment of cardiomyopathy via titin isoform switching
|
|---|---|
| Published in |
Biophysical Reviews, June 2017
|
| DOI | 10.1007/s12551-017-0267-5 |
| Pubmed ID | |
| Authors |
Wei Guo, Mingming Sun |
| Abstract |
Cardiomyopathy, also known as heart muscle disease, is an unfavorable condition leading to alterations in myocardial contraction and/or impaired ability of ventricular filling. The onset and development of cardiomyopathy have not currently been well defined. Titin is a giant multifunctional sarcomeric filament protein that provides passive stiffness to cardiomyocytes and has been implicated to play an important role in the origin and development of cardiomyopathy and heart failure. Titin-based passive stiffness can be mainly adjusted by isoform switching and post-translational modifications in the spring regions. Recently, genetic mutations of TTN have been identified that can also contribute to variable passive stiffness, though the detailed mechanisms remain unclear. In this review, we will discuss titin isoform switching as it relates to alternative splicing during development stages and differences between species and muscle types. We provide an update on the regulatory mechanisms of TTN splicing controlled by RBM20 and cover the roles of TTN splicing in adjusting the diastolic stiffness and systolic compliance of the healthy and the failing heart. Finally, this review attempts to provide future directions for RBM20 as a potential target for pharmacological intervention in cardiomyopathy and heart failure. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 35% |
| Student > Ph. D. Student | 8 | 15% |
| Other | 7 | 13% |
| Student > Bachelor | 4 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 24% |
| Medicine and Dentistry | 10 | 19% |
| Agricultural and Biological Sciences | 8 | 15% |
| Chemistry | 5 | 9% |
| Social Sciences | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 12 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#4,750,811
of 23,706,541 outputs
Outputs from Biophysical Reviews
#90
of 829 outputs
Outputs of similar age
#81,858
of 318,591 outputs
Outputs of similar age from Biophysical Reviews
#2
of 10 outputs
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So far Altmetric has tracked 829 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 89% of its peers.
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