| Title |
RETRACTED ARTICLE: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency
|
|---|---|
| Published in |
Nature, January 2014
|
| DOI | 10.1038/nature12969 |
| Pubmed ID | |
| Authors |
Haruko Obokata, Yoshiki Sasai, Hitoshi Niwa, Mitsutaka Kadota, Munazah Andrabi, Nozomu Takata, Mikiko Tokoro, Yukari Terashita, Shigenobu Yonemura, Charles A. Vacanti, Teruhiko Wakayama |
| Abstract |
We recently discovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acquisition of pluripotency (STAP). This reprogramming does not require nuclear transfer or genetic manipulation. Here we report that reprogrammed STAP cells, unlike embryonic stem (ES) cells, can contribute to both embryonic and placental tissues, as seen in a blastocyst injection assay. Mouse STAP cells lose the ability to contribute to the placenta as well as trophoblast marker expression on converting into ES-like stem cells by treatment with adrenocorticotropic hormone (ACTH) and leukaemia inhibitory factor (LIF). In contrast, when cultured with Fgf4, STAP cells give rise to proliferative stem cells with enhanced trophoblastic characteristics. Notably, unlike conventional trophoblast stem cells, the Fgf4-induced stem cells from STAP cells contribute to both embryonic and placental tissues in vivo and transform into ES-like cells when cultured with LIF-containing medium. Taken together, the developmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicates that they represent a unique state of pluripotency. |
X Demographics
The data shown below were collected from the profiles of 775 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 281 | 36% |
| United States | 25 | 3% |
| Australia | 10 | 1% |
| United Kingdom | 8 | 1% |
| France | 5 | <1% |
| Spain | 3 | <1% |
| Ireland | 3 | <1% |
| Canada | 3 | <1% |
| Taiwan | 2 | <1% |
| Other | 26 | 3% |
| Unknown | 409 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 708 | 91% |
| Scientists | 51 | 7% |
| Practitioners (doctors, other healthcare professionals) | 10 | 1% |
| Science communicators (journalists, bloggers, editors) | 5 | <1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 2,262 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 70 | 3% |
| United States | 30 | 1% |
| United Kingdom | 12 | <1% |
| France | 9 | <1% |
| Spain | 5 | <1% |
| Germany | 5 | <1% |
| Brazil | 4 | <1% |
| China | 4 | <1% |
| Netherlands | 3 | <1% |
| Other | 27 | 1% |
| Unknown | 2093 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 601 | 27% |
| Student > Ph. D. Student | 440 | 19% |
| Student > Master | 229 | 10% |
| Professor > Associate Professor | 208 | 9% |
| Student > Bachelor | 185 | 8% |
| Other | 448 | 20% |
| Unknown | 151 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 988 | 44% |
| Medicine and Dentistry | 306 | 14% |
| Biochemistry, Genetics and Molecular Biology | 245 | 11% |
| Chemistry | 107 | 5% |
| Engineering | 102 | 5% |
| Other | 321 | 14% |
| Unknown | 193 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1579. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#7,255
of 25,789,020 outputs
Outputs from Nature
#777
of 98,781 outputs
Outputs of similar age
#37
of 325,521 outputs
Outputs of similar age from Nature
#7
of 888 outputs
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