| Title |
Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator
|
|---|---|
| Published in |
BMC Medical Genomics, January 2014
|
| DOI | 10.1186/1755-8794-7-5 |
| Pubmed ID | |
| Authors |
Theresa Swift-Scanlan, Christopher T Smith, Sabrina A Bardowell, Charlotte A Boettiger |
| Abstract |
The catechol-O-methyltransferase (COMT) enzyme has been widely studied due to its multiple roles in neurological functioning, estrogen biology, and methylation metabolic pathways. Numerous studies have investigated variation in the large COMT gene, with the majority focusing on single nucleotide polymorphisms (SNPs). This body of work has linked COMT genetic variation with a vast array of conditions, including several neurobehavioral disorders, pain sensitivity, and multiple human cancers. Based on COMT's numerous biological roles and recent studies suggesting that methylation of the COMT gene impacts COMT gene expression, we comprehensively interrogated methylation in over 200 CpG dinucleotide sequences spanning the length of the COMT gene. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 18% |
| Student > Master | 10 | 14% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 4 | 6% |
| Other | 15 | 21% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 21% |
| Agricultural and Biological Sciences | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Neuroscience | 6 | 8% |
| Nursing and Health Professions | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 16 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2018.
All research outputs
#2,693,926
of 22,741,406 outputs
Outputs from BMC Medical Genomics
#101
of 1,218 outputs
Outputs of similar age
#33,504
of 306,092 outputs
Outputs of similar age from BMC Medical Genomics
#1
of 11 outputs
Altmetric has tracked 22,741,406 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,218 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.