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Association Between Prenatal Alcohol Exposure and Craniofacial Shape of Children at 12 Months of Age

Overview of attention for article published in JAMA Pediatrics, August 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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40 news outlets
blogs
3 blogs
policy
1 policy source
twitter
366 X users
facebook
41 Facebook pages
googleplus
6 Google+ users
reddit
5 Redditors

Citations

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94 Dimensions

Readers on

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147 Mendeley
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Title
Association Between Prenatal Alcohol Exposure and Craniofacial Shape of Children at 12 Months of Age
Published in
JAMA Pediatrics, August 2017
DOI 10.1001/jamapediatrics.2017.0778
Pubmed ID
Authors

Evelyne Muggli, Harold Matthews, Anthony Penington, Peter Claes, Colleen O’Leary, Della Forster, Susan Donath, Peter J. Anderson, Sharon Lewis, Cate Nagle, Jeffrey M. Craig, Susan M. White, Elizabeth J. Elliott, Jane Halliday

Abstract

Children who receive a diagnosis of fetal alcohol spectrum disorder may have a characteristic facial appearance in addition to neurodevelopmental impairment. It is not well understood whether there is a gradient of facial characteristics of children who did not receive a diagnosis of fetal alcohol spectrum disorder but who were exposed to a range of common drinking patterns during pregnancy. To examine the association between dose, frequency, and timing of prenatal alcohol exposure and craniofacial phenotype in 12-month-old children. A prospective cohort study was performed from January 1, 2011, to December 30, 2014, among mothers recruited in the first trimester of pregnancy from low-risk, public maternity clinics in metropolitan Melbourne, Australia. A total of 415 white children were included in this analysis of 3-dimensional craniofacial images taken at 12 months of age. Analysis was performed with objective, holistic craniofacial phenotyping using dense surface models of the face and head. Partial least square regression models included covariates known to affect craniofacial shape. Low, moderate to high, or binge-level alcohol exposure in the first trimester or throughout pregnancy. Anatomical differences in global and regional craniofacial shape between children of women who abstained from alcohol during pregnancy and children with varying levels of prenatal alcohol exposure. Of the 415 children in the study (195 girls and 220 boys; mean [SD] age, 363.0 [8.3] days), a consistent association between craniofacial shape and prenatal alcohol exposure was observed at almost any level regardless of whether exposure occurred only in the first trimester or throughout pregnancy. Regions of difference were concentrated around the midface, nose, lips, and eyes. Directional visualization showed that these differences corresponded to general recession of the midface and superior displacement of the nose, especially the tip of the nose, indicating shortening of the nose and upturning of the nose tip. Differences were most pronounced between groups with no exposure and groups with low exposure in the first trimester (forehead), moderate to high exposure in the first trimester (eyes, midface, chin, and parietal region), and binge-level exposure in the first trimester (chin). Prenatal alcohol exposure, even at low levels, can influence craniofacial development. Although the clinical significance of these findings is yet to be determined, they support the conclusion that for women who are or may become pregnant, avoiding alcohol is the safest option.

X Demographics

X Demographics

The data shown below were collected from the profiles of 366 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 147 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 12%
Researcher 17 12%
Student > Ph. D. Student 16 11%
Student > Bachelor 15 10%
Other 13 9%
Other 23 16%
Unknown 45 31%
Readers by discipline Count As %
Medicine and Dentistry 45 31%
Nursing and Health Professions 11 7%
Psychology 10 7%
Biochemistry, Genetics and Molecular Biology 8 5%
Agricultural and Biological Sciences 7 5%
Other 15 10%
Unknown 51 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 610. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2023.
All research outputs
#37,446
of 25,584,565 outputs
Outputs from JAMA Pediatrics
#167
of 6,728 outputs
Outputs of similar age
#731
of 328,005 outputs
Outputs of similar age from JAMA Pediatrics
#4
of 80 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,728 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 79.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,005 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.