Title |
Interaction of molecular alterations with immune response in melanoma
|
---|---|
Published in |
Cancer (0008543X), May 2017
|
DOI | 10.1002/cncr.30681 |
Pubmed ID | |
Authors |
Robert A. Szczepaniak Sloane, Vancheswaran Gopalakrishnan, Sangeetha M. Reddy, Xue Zhang, Alexandre Reuben, Jennifer A. Wargo |
Abstract |
Major advances have been made in melanoma treatment with the use of molecularly targeted therapies and immunotherapies, and numerous regimens are now approved by the US Food and Drug Administration for patients with stage IV disease. However, therapeutic resistance remains an issue to both classes of agents, and reliable biomarkers of therapeutic response and resistance are lacking. Mechanistic insights are being gained through preclinical studies and translational research, offering potential strategies to enhance responses and survival in treated patients. A comprehensive understanding of the immune effects of common mutations at play in melanoma is critical, as is an appreciation of the molecular mechanisms contributing to therapeutic resistance to immunotherapy. These mechanisms and the interplay between them are discussed herein. Cancer 2017;123:2130-42. © 2017 American Cancer Society. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
Poland | 1 | 13% |
United Kingdom | 1 | 13% |
Spain | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 38% |
Scientists | 2 | 25% |
Science communicators (journalists, bloggers, editors) | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 17% |
Researcher | 11 | 14% |
Student > Ph. D. Student | 7 | 9% |
Student > Master | 5 | 7% |
Student > Doctoral Student | 4 | 5% |
Other | 12 | 16% |
Unknown | 24 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 25% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Agricultural and Biological Sciences | 9 | 12% |
Immunology and Microbiology | 7 | 9% |
Nursing and Health Professions | 1 | 1% |
Other | 3 | 4% |
Unknown | 26 | 34% |