| Title |
Plasma irisin levels predict telomere length in healthy adults
|
|---|---|
| Published in |
GeroScience, January 2014
|
| DOI | 10.1007/s11357-014-9620-9 |
| Pubmed ID | |
| Authors |
Karan S. Rana, Muhammad Arif, Eric J. Hill, Sarah Aldred, David A. Nagel, Alan Nevill, Harpal S. Randeva, Clifford J. Bailey, Srikanth Bellary, James E. Brown |
| Abstract |
The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43 ± 15.8 years, BMI 24.3 ± 2.9 kg/m(2)). Data showed significant correlations between log-transformed relative telomere length and the following: age (p < 0.001), height (p = 0.045), total body fat percentage (p = 0.031), abdominal fat percentage (p = 0.038), visceral fat level (p < 0.001), plasma leptin (p = 0.029) and plasma irisin (p = 0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b = -0.00735, p = 0.001) and plasma irisin levels (b = 0.04527, p = 0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Philippines | 1 | 7% |
| Canada | 1 | 7% |
| United States | 1 | 7% |
| Hungary | 1 | 7% |
| United Kingdom | 1 | 7% |
| Germany | 1 | 7% |
| Norway | 1 | 7% |
| Unknown | 7 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 71% |
| Scientists | 3 | 21% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 3% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Russia | 1 | <1% |
| Iraq | 1 | <1% |
| Unknown | 100 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 18% |
| Student > Ph. D. Student | 15 | 14% |
| Researcher | 13 | 12% |
| Student > Bachelor | 12 | 11% |
| Other | 6 | 6% |
| Other | 25 | 23% |
| Unknown | 18 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 22% |
| Sports and Recreations | 14 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 11% |
| Agricultural and Biological Sciences | 12 | 11% |
| Neuroscience | 4 | 4% |
| Other | 21 | 19% |
| Unknown | 21 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2023.
All research outputs
#644,775
of 26,017,215 outputs
Outputs from GeroScience
#83
of 1,655 outputs
Outputs of similar age
#6,598
of 329,676 outputs
Outputs of similar age from GeroScience
#2
of 16 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.