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New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins

Overview of attention for book
Cover of 'New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 12 Downstream Processing Technologies/Capturing and Final Purification
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    Chapter 14 Platforms for Manufacturing Allogeneic, Autologous and iPSC Cell Therapy Products: An Industry Perspective
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    Chapter 18 Trends in Process Analytical Technology: Present State in Bioprocessing
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    Chapter 19 Fully Disposable Manufacturing Concepts for Clinical and Commercial Manufacturing and Ballroom Concepts
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    Chapter 20 High-Throughput Process Development for Biopharmaceuticals
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    Chapter 38 Risk Mitigation in Preventing Adventitious Agent Contamination of Mammalian Cell Cultures
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    Chapter 39 An Introduction to „Recent Trends in the Biotechnology Industry: Development and Manufacturing of Recombinant Antibodies and Proteins“
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    Chapter 53 Gene Therapy
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    Chapter 54 Manufacturing of Proteins and Antibodies: Chapter Downstream Processing Technologies
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    Chapter 55 New Mammalian Expression Systems
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    Chapter 56 Innovation in Cell Banking, Expansion, and Production Culture
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    Chapter 57 Next Generation Biopharmaceuticals: Product Development
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    Chapter 58 Continuous Manufacturing of Recombinant Therapeutic Proteins: Upstream and Downstream Technologies
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    Chapter 59 A Different Perspective: How Much Innovation Is Really Needed for Monoclonal Antibody Production Using Mammalian Cell Technology?
Attention for Chapter 55: New Mammalian Expression Systems
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Citations

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Chapter title
New Mammalian Expression Systems
Chapter number 55
Book title
Advances in Biochemical Engineering/Biotechnology
Published in
Advances in biochemical engineering biotechnology, June 2017
DOI 10.1007/10_2016_55
Pubmed ID
28585079
Book ISBNs
978-3-31-997108-7, 978-3-31-997110-0
Authors

Zhu, Jie, Hatton, Diane, Jie Zhu, Diane Hatton

Abstract

There are an increasing number of recombinant antibodies and proteins in preclinical and clinical development for therapeutic applications. Mammalian expression systems are key to enabling the production of these molecules, and Chinese hamster ovary (CHO) cell platforms continue to be central to delivery of the stable cell lines required for large-scale production. Increasing pressure on timelines and efficiency, further innovation of molecular formats and the shift to new production systems are driving developments of these CHO cell line platforms. The availability of genome and transcriptome data coupled with advancing gene editing tools are increasing the ability to design and engineer CHO cell lines to meet these challenges. This chapter aims to give an overview of the developments in CHO expression systems and some of the associated technologies over the past few years.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 26%
Student > Ph. D. Student 6 11%
Student > Bachelor 4 7%
Student > Postgraduate 3 6%
Other 1 2%
Other 3 6%
Unknown 23 43%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 31%
Agricultural and Biological Sciences 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Immunology and Microbiology 2 4%
Nursing and Health Professions 1 2%
Other 3 6%
Unknown 22 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2017.
All research outputs
#15,464,404
of 22,979,862 outputs
Outputs from Advances in biochemical engineering biotechnology
#114
of 225 outputs
Outputs of similar age
#199,213
of 317,259 outputs
Outputs of similar age from Advances in biochemical engineering biotechnology
#3
of 5 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 225 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,259 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.

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