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Activity-dependent regulation of inhibitory synapse development by Npas4

Overview of attention for article published in Nature, September 2008
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
12 news outlets
twitter
1 X user
patent
3 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
513 Dimensions

Readers on

mendeley
699 Mendeley
citeulike
3 CiteULike
connotea
3 Connotea
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Title
Activity-dependent regulation of inhibitory synapse development by Npas4
Published in
Nature, September 2008
DOI 10.1038/nature07319
Pubmed ID
Authors

Yingxi Lin, Brenda L. Bloodgood, Jessica L. Hauser, Ariya D. Lapan, Alex C. Koon, Tae-Kyung Kim, Linda S. Hu, Athar N. Malik, Michael E. Greenberg

Abstract

Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 699 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 19 3%
Japan 7 1%
Germany 4 <1%
United Kingdom 4 <1%
France 2 <1%
Portugal 2 <1%
Singapore 2 <1%
Netherlands 1 <1%
Brazil 1 <1%
Other 7 1%
Unknown 650 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 182 26%
Researcher 166 24%
Student > Master 54 8%
Professor > Associate Professor 44 6%
Student > Bachelor 39 6%
Other 116 17%
Unknown 98 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 272 39%
Neuroscience 182 26%
Biochemistry, Genetics and Molecular Biology 54 8%
Medicine and Dentistry 42 6%
Engineering 11 2%
Other 33 5%
Unknown 105 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 88. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2023.
All research outputs
#451,488
of 24,378,020 outputs
Outputs from Nature
#21,259
of 94,893 outputs
Outputs of similar age
#841
of 92,762 outputs
Outputs of similar age from Nature
#34
of 552 outputs
Altmetric has tracked 24,378,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 94,893 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 101.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,762 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 552 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.