Title |
Regulating STING in health and disease
|
---|---|
Published in |
Journal of Inflammation, June 2017
|
DOI | 10.1186/s12950-017-0159-2 |
Pubmed ID | |
Authors |
Yang Li, Heather L. Wilson, Endre Kiss-Toth |
Abstract |
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named "STimulator of INterferon Genes (STING)". STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. This review will summarise the recent structural and functional findings of STING, and discuss how STING research has promoted the development of novel therapeutic approaches and experimental tools to improve treatment of tumour and autoimmune diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 83% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Scientists | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 175 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 19% |
Student > Ph. D. Student | 31 | 18% |
Student > Master | 20 | 11% |
Student > Bachelor | 18 | 10% |
Other | 9 | 5% |
Other | 16 | 9% |
Unknown | 48 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 40 | 23% |
Agricultural and Biological Sciences | 21 | 12% |
Immunology and Microbiology | 17 | 10% |
Medicine and Dentistry | 16 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
Other | 18 | 10% |
Unknown | 54 | 31% |