| Title |
Multiple gene movements into and out of haploid sex chromosomes
|
|---|---|
| Published in |
Genome Biology, June 2017
|
| DOI | 10.1186/s13059-017-1201-7 |
| Pubmed ID | |
| Authors |
Agnieszka P. Lipinska, Nicholas R. T. Toda, Svenja Heesch, Akira F. Peters, J. Mark Cock, Susana M. Coelho |
| Abstract |
Long-term evolution of sex chromosomes is a dynamic process shaped by gene gain and gene loss. Sex chromosome gene traffic has been studied in XY and ZW systems but no detailed analyses have been carried out for haploid phase UV sex chromosomes. Here, we explore sex-specific sequences of seven brown algal species to understand the dynamics of the sex-determining region (SDR) gene content across 100 million years of evolution. A core set of sex-linked genes is conserved across all the species investigated, but we also identify modifications of both the U and the V SDRs that occurred in a lineage-specific fashion. These modifications involve gene loss, gene gain and relocation of genes from the SDR to autosomes. Evolutionary analyses suggest that the SDR genes are evolving rapidly and that this is due to relaxed purifying selection. Expression analysis indicates that genes that were acquired from the autosomes have been retained in the SDR because they confer a sex-specific role in reproduction. By examining retroposed genes in Saccharina japonica, we demonstrate that UV sex chromosomes have generated a disproportionate number of functional orphan retrogenes compared with autosomes. Movement of genes out of the UV sex chromosome could be a means to compensate for gene loss from the non-recombining region, as has been suggested for Y-derived retrogenes in XY sexual systems. This study provides the first analysis of gene traffic in a haploid UV system and identifies several features of general relevance to the evolution of sex chromosomes. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 19% |
| United States | 2 | 10% |
| Switzerland | 1 | 5% |
| Canada | 1 | 5% |
| Indonesia | 1 | 5% |
| Austria | 1 | 5% |
| France | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 9 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 71% |
| Scientists | 5 | 24% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 56 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 21% |
| Researcher | 11 | 19% |
| Student > Bachelor | 9 | 16% |
| Student > Master | 8 | 14% |
| Student > Doctoral Student | 5 | 9% |
| Other | 6 | 11% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 54% |
| Biochemistry, Genetics and Molecular Biology | 14 | 25% |
| Environmental Science | 1 | 2% |
| Computer Science | 1 | 2% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2021.
All research outputs
#2,549,863
of 25,382,440 outputs
Outputs from Genome Biology
#2,041
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Outputs of similar age
#46,769
of 331,454 outputs
Outputs of similar age from Genome Biology
#45
of 65 outputs
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