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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gold nanoparticles enhance 5-fluorouracil anticancer efficacy against colorectal cancer cells
|
|---|---|
| Published in |
International Journal of Pharmaceutics, September 2016
|
| DOI | 10.1016/j.ijpharm.2016.09.076 |
| Pubmed ID | |
| Authors |
Mohamed A. Safwat, Ghareb M. Soliman, Douaa Sayed, Mohamed A. Attia |
| Abstract |
5-Fluorouracil (5-FU), an antimetabolite drug, is extensively used in the treatment solid tumors. However, its severe side effects limit its clinical benefits. To enhance 5-FU anticancer efficacy and reduce its side effects it was loaded onto gold nanoparticles (GNPs) using two thiol containing ligands, thioglycolic acid (TGA) and glutathione (GSH). The GNPs were prepared at different 5-FU/ligand molar ratios and evaluated using different techniques. Anticancer efficacy of 5-FU/GSH-GNPs was studied using flow cytometry in cancerous tissue obtained from patients having colorectal cancer. The GNPs were spherical in shape and had a size of ∼9-17nm. Stability of the GNPs and drug release were studied as a function of salt concentration and solution pH. Maximum 5-FU loading was achieved at 5-FU/ligand molar ratio of 1:1 and 2:1 for TGA-GNPs and GSH-GNPs, respectively. GNPs coating with pluronic F127 improved their stability against salinity. 5-FU release from GNPs was slow and pH-dependent. 5-FU/GSH-GNPs induced apoptosis and stopped the cell cycle progression in colorectal cancer cells. They also had a 2-fold higher anticancer effect compared with free 5-FU. These results confirm the potential of GNPs to enhance 5-FU anticancer efficacy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 13% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 10 | 9% |
| Professor > Associate Professor | 9 | 8% |
| Researcher | 7 | 6% |
| Other | 13 | 12% |
| Unknown | 42 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 18% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Engineering | 7 | 6% |
| Chemistry | 6 | 6% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 15 | 14% |
| Unknown | 48 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2017.
All research outputs
#16,722,190
of 25,374,647 outputs
Outputs from International Journal of Pharmaceutics
#6,192
of 8,180 outputs
Outputs of similar age
#205,805
of 330,428 outputs
Outputs of similar age from International Journal of Pharmaceutics
#53
of 100 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,180 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,428 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.