Title |
Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation
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Published in |
Internal and Emergency Medicine, November 2011
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DOI | 10.1007/s11739-011-0727-z |
Pubmed ID | |
Authors |
Ernesto Crisafulli, Elena Venturelli, Gianluca Biscione, Guido Vagheggini, Andrea Iattoni, Sasha Lucic, Nicolino Ambrosino, Franco Pasqua, Alfredo Cesario, Enrico Maria Clini |
Abstract |
The role of pulmonary rehabilitation (PR) in COPD patients with lung hyperinflation has not yet been fully investigated. We retrospectively evaluated the effect of a standard PR course on exercise tolerance and symptoms according to the presence or absence of associated lung hyperinflation, as defined by lung function parameters in three Italian rehabilitation centres. In a cohort of 823 COPD patients (age 71 ± 8 years, FEV1 56 ± 18% pred.) we have systematically recorded: changes (∆) in 6-minute walking test (6MWD) as the primary outcome; dyspnoea (D); muscle fatigue (F); SO2nadir during effort; perceived breathlessness score (MRC); and specific health-related quality of life (SGRQ). Outcomes were compared between patients with lung hyperinflation (n = 283, LH) or without (n = 540 No-LH). Groups were comparable for age, body mass index, baseline exercise tolerance, and breathlessness. ∆-6MWD (+72 ± 47 vs. +62 ± 42 m, p < 0.05); ∆-D (-2.3 ± 1.7 vs. -1.9 ± 1.3 point, p < 0.05) and ∆-SO2nadir (+1.4 ± 3.0 and +0.5 ± 3.3 point, p < 0.05) were greater in LH than in No-LH. Using a multivariate linear regression model, ∆-6MWD in the LH group significantly correlated with lower functional residual capacity (p = 0.021) and baseline 6MWD (p = 0.004). Tolerance, gas exchange and perceived symptoms during effort are the parameters that gain a significant benefit from standard rehabilitation in COPD patients with a lung hyperinflation condition. |
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Country | Count | As % |
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Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 18% |
Student > Master | 6 | 15% |
Student > Doctoral Student | 3 | 8% |
Student > Bachelor | 3 | 8% |
Professor | 2 | 5% |
Other | 6 | 15% |
Unknown | 12 | 31% |
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Sports and Recreations | 5 | 13% |
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Agricultural and Biological Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 15 | 38% |