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Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

Overview of attention for article published in Nature Reviews Endocrinology, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

twitter
176 X users
patent
12 patents
facebook
10 Facebook pages
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
457 Dimensions

Readers on

mendeley
428 Mendeley
citeulike
2 CiteULike
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Title
Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
Published in
Nature Reviews Endocrinology, June 2017
DOI 10.1038/nrendo.2017.56
Pubmed ID
Authors

Ruth C. R. Meex, Matthew J. Watt

Abstract

Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver disease and is present in up to ∼70% of individuals who are overweight. NAFLD is also associated with hypertriglyceridaemia and low levels of HDL, glucose intolerance, insulin resistance and type 2 diabetes mellitus. Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle. Hepatokines are proteins that are secreted by hepatocytes, and many hepatokines have been linked to the induction of metabolic dysfunction, including fetuin A, fetuin B, retinol-binding protein 4 (RBP4) and selenoprotein P. In this Review, we describe the factors that influence the development of hepatic steatosis, provide evidence of strong links between hepatic steatosis and insulin resistance in non-hepatic tissues, and discuss recent advances in our understanding of how steatosis alters hepatokine secretion to influence metabolic phenotypes through inter-organ communication.

X Demographics

X Demographics

The data shown below were collected from the profiles of 176 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 428 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 428 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 61 14%
Student > Ph. D. Student 58 14%
Researcher 50 12%
Student > Bachelor 37 9%
Student > Doctoral Student 30 7%
Other 81 19%
Unknown 111 26%
Readers by discipline Count As %
Medicine and Dentistry 95 22%
Biochemistry, Genetics and Molecular Biology 92 21%
Agricultural and Biological Sciences 37 9%
Immunology and Microbiology 12 3%
Pharmacology, Toxicology and Pharmaceutical Science 11 3%
Other 44 10%
Unknown 137 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 105. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#400,691
of 25,403,829 outputs
Outputs from Nature Reviews Endocrinology
#118
of 2,588 outputs
Outputs of similar age
#8,493
of 331,460 outputs
Outputs of similar age from Nature Reviews Endocrinology
#4
of 47 outputs
Altmetric has tracked 25,403,829 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,588 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.