| Title |
Abnormal baseline brain activity in Alzheimer’s disease patients with depression: a resting-state functional magnetic resonance imaging study
|
|---|---|
| Published in |
Neuroradiology, June 2017
|
| DOI | 10.1007/s00234-017-1854-7 |
| Pubmed ID | |
| Authors |
Xiaozheng Liu, Zhongwei Guo, Yanping Ding, Jiapeng Li, Gang Wang, Hongtao Hou, Xingli Chen, Enyan Yu |
| Abstract |
As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood. The current study sought to investigate low-frequency oscillations at the voxel level in D-AD patients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging. We examined 22 D-AD patients and 21 non-depressed AD (nD-AD) patients. The results revealed that D-AD patients exhibited increased ALFF values in the left caudate and thalamus and decreased ALFF values in the left middle temporal pole compared with nD-AD patients. These findings may provide further insight into the underlying neuropathophysiology of AD with depression. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 20% |
| Student > Bachelor | 7 | 16% |
| Student > Master | 6 | 13% |
| Researcher | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Other | 4 | 9% |
| Unknown | 12 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 24% |
| Neuroscience | 7 | 16% |
| Medicine and Dentistry | 5 | 11% |
| Nursing and Health Professions | 3 | 7% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 1 | 2% |
| Unknown | 16 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2017.
All research outputs
#3,226,004
of 22,979,862 outputs
Outputs from Neuroradiology
#83
of 1,398 outputs
Outputs of similar age
#61,841
of 317,472 outputs
Outputs of similar age from Neuroradiology
#2
of 28 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,398 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,472 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.