| Title |
Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells
|
|---|---|
| Published in |
Biotechnology Techniques, October 2013
|
| DOI | 10.1007/s10529-013-1382-4 |
| Pubmed ID | |
| Authors |
Leonardo G. Monte, Tatiane Santi-Gadelha, Larissa B. Reis, Elizandra Braganhol, Rafael F. Prietsch, Odir A. Dellagostin, Rodrigo Rodrigues e Lacerda, Carlos A. A. Gadelha, Fabricio R. Conceição, Luciano S. Pinto |
| Abstract |
The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 21% |
| United Kingdom | 4 | 17% |
| Germany | 1 | 4% |
| New Zealand | 1 | 4% |
| Uganda | 1 | 4% |
| Unknown | 12 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 92% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 93 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 15% |
| Student > Bachelor | 12 | 13% |
| Researcher | 11 | 12% |
| Student > Ph. D. Student | 8 | 8% |
| Professor | 4 | 4% |
| Other | 14 | 15% |
| Unknown | 32 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 21% |
| Biochemistry, Genetics and Molecular Biology | 15 | 16% |
| Chemistry | 6 | 6% |
| Medicine and Dentistry | 5 | 5% |
| Computer Science | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 36 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 182. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2022.
All research outputs
#219,937
of 25,373,627 outputs
Outputs from Biotechnology Techniques
#1
of 2,762 outputs
Outputs of similar age
#1,548
of 223,606 outputs
Outputs of similar age from Biotechnology Techniques
#1
of 28 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,762 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.