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Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment

Overview of attention for article published in Human Molecular Genetics, January 2014
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1 X user
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1 Wikipedia page

Citations

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75 Dimensions

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108 Mendeley
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Title
Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment
Published in
Human Molecular Genetics, January 2014
DOI 10.1093/hmg/ddu047
Pubmed ID
Authors

A. Jennifer Morton, Skye R. Rudiger, Nigel I. Wood, Stephen J. Sawiak, Gregory C. Brown, Clive J. Mclaughlan, Timothy R. Kuchel, Russell G. Snell, Richard L.M. Faull, C. Simon Bawden

Abstract

Insidious changes in behaviour herald the onset of progressive neurodegenerative disorders such as Huntington's disease (HD), sometimes years before overt symptoms are seen. Sleep and circadian disturbances are particularly disruptive symptoms in patients with neurological disorders, but they are difficult to measure in humans. Here we studied circadian behaviour in transgenic HD sheep expressing the full-length human huntingtin protein with an expanded CAG repeat mutation in the juvenile range. Young HD sheep with no other symptoms exhibited circadian behavioural abnormalities that worsened with age. The most obvious change was a disturbed evening behaviour reminiscent of 'sundowning' that is seen in some patients with dementia. There were no structural abnormalities seen with magnetic resonance imaging, even in 5-year-old HD sheep. Interestingly, detection of the circadian abnormalities depended upon their social grouping. Abnormalities emerged in sheep kept in an 'HD-only' flock, whereas the behaviour of HD sheep kept mixed with normal sheep was relatively normal. Sleep-wake abnormalities in HD patients are also likely to be hidden, and may precede overt symptoms by many years. Sleep disruption has deleterious effects, even in normal people. The knock-on effects of sleep-wake disturbance may exacerbate, or even cause symptoms such as irritability and depression that are common in early stage HD patients. HD sheep will be useful models for probing the mechanisms underlying circadian behavioural disorder in HD.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Czechia 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 103 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 23%
Student > Bachelor 12 11%
Student > Ph. D. Student 11 10%
Student > Master 10 9%
Student > Doctoral Student 8 7%
Other 23 21%
Unknown 19 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 23%
Neuroscience 22 20%
Medicine and Dentistry 11 10%
Biochemistry, Genetics and Molecular Biology 7 6%
Psychology 6 6%
Other 14 13%
Unknown 23 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2017.
All research outputs
#7,196,142
of 22,743,667 outputs
Outputs from Human Molecular Genetics
#3,599
of 8,020 outputs
Outputs of similar age
#88,183
of 306,968 outputs
Outputs of similar age from Human Molecular Genetics
#44
of 90 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 8,020 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.