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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice
|
|---|---|
| Published in |
Diabetes and Vascular Disease Research, February 2017
|
| DOI | 10.1177/1479164117692766 |
| Pubmed ID | |
| Authors |
Hooi H Ng, Gunes S Yildiz, Jacqueline M Ku, Alyson A Miller, Owen L Woodman, Joanne L Hart |
| Abstract |
Hydrogen sulphide (H2S) is endogenously produced in vascular tissue and has anti-oxidant and vasoprotective properties. This study investigates whether chronic treatment using the fast H2S donor NaHS could elicit a vasoprotective effect in diabetes. Diabetes was induced in male C57BL6/J mice with streptozotocin (60 mg/kg daily, ip for 2 weeks) and confirmed by elevated blood glucose and glycated haemoglobin levels. Diabetic mice were then treated with NaHS (100 µmol/kg/day) for 4 weeks, and aortae collected for functional and biochemical analyses. In the diabetic group, both endothelium-dependent vasorelaxation and basal nitric oxide (NO(•)) bioactivity were significantly reduced ( p < 0.05), and maximal vasorelaxation to the NO(•) donor sodium nitroprusside was impaired ( p < 0.05) in aorta compared to control mice. Vascular superoxide generation via nicotine adenine dinucleotide phosphate (NADPH) oxidase ( p < 0.05) was elevated in aorta from diabetic mice which was associated with increased expression of NOX2 ( p < 0.05). NaHS treatment of diabetic mice restored endothelial function and exogenous NO(•) efficacy back to control levels. NaHS treatment also reduced the diabetes-induced increase in NADPH oxidase activity, but did not affect NOX2 protein expression. These data show that chronic NaHS treatment reverses diabetes-induced vascular dysfunction by restoring NO(•) efficacy and reducing superoxide production in the mouse aorta. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 10% |
| Student > Doctoral Student | 3 | 10% |
| Professor | 3 | 10% |
| Student > Bachelor | 2 | 7% |
| Researcher | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 11 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 17% |
| Agricultural and Biological Sciences | 4 | 14% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Medicine and Dentistry | 3 | 10% |
| Neuroscience | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 10 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2017.
All research outputs
#15,694,282
of 23,321,213 outputs
Outputs from Diabetes and Vascular Disease Research
#211
of 339 outputs
Outputs of similar age
#258,690
of 422,128 outputs
Outputs of similar age from Diabetes and Vascular Disease Research
#7
of 10 outputs
Altmetric has tracked 23,321,213 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 339 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,128 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.