| Title |
Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord
|
|---|---|
| Published in |
Neural Development, June 2017
|
| DOI | 10.1186/s13064-017-0087-0 |
| Pubmed ID | |
| Authors |
Julien Laussu, Christophe Audouard, Anthony Kischel, Poincyane Assis-Nascimento, Nathalie Escalas, Daniel J. Liebl, Cathy Soula, Alice Davy |
| Abstract |
In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also their proliferation and differentiation rates. Although the initial steps of pMN specification have been extensively studied, how pMN numbers are regulated over time is less well characterized. Here, we show that ephrinB2 and ephrinB3 are differentially expressed in progenitor domains in the ventral spinal cord with several Eph receptors more broadly expressed. Genetic loss-of-function analyses show that ephrinB2 and ephrinB3 inversely control pMN numbers and that these changes in progenitor numbers correlate with changes in motor neuron numbers. Detailed phenotypic analyses by immunostaining and genetic interaction studies between ephrinB2 and Shh indicate that changes in pMN numbers in ephrin mutants are due to alteration in progenitor identity at late stages of development. Altogether our data reveal that Eph:ephrin signaling is required to control progenitor identities in the ventral spinal cord. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 32% |
| Student > Ph. D. Student | 5 | 26% |
| Student > Doctoral Student | 3 | 16% |
| Student > Master | 2 | 11% |
| Other | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 42% |
| Biochemistry, Genetics and Molecular Biology | 7 | 37% |
| Medicine and Dentistry | 1 | 5% |
| Chemistry | 1 | 5% |
| Engineering | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 1 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2017.
All research outputs
#17,898,929
of 22,979,862 outputs
Outputs from Neural Development
#163
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Outputs of similar age
#226,975
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Outputs of similar age from Neural Development
#4
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