Title |
Acute kidney injury: emerging pharmacotherapies in current clinical trials
|
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Published in |
Pediatric Nephrology, June 2017
|
DOI | 10.1007/s00467-017-3695-3 |
Pubmed ID | |
Authors |
Stefanie Woolridge Benoit, Prasad Devarajan |
Abstract |
Acute kidney injury (AKI) is a significant source of morbidity and mortality in pediatric patients, affecting more than one quarter of critically ill children. Despite significant need, there are no targeted therapies to reliably prevent or treat AKI. Recent advances in our understanding of renal injury and repair signaling pathways have enabled the development of several targeted pharmaceuticals. Here we review emerging pharmacotherapies for AKI that are currently in clinical trials. Categorized by their general mechanism of action, the therapies discussed include anti-inflammatory agents (recAP, AB103, ABT-719), antioxidants (iron chelators, heme arginate), vasodilators (levosimendan), apoptosis inhibitors (QPI-1002), and repair agents (THR-184, BB-3, mesenchymal stem cells). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 25% |
Canada | 2 | 17% |
United Kingdom | 1 | 8% |
Unknown | 6 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Science communicators (journalists, bloggers, editors) | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 17% |
Other | 7 | 15% |
Student > Bachelor | 6 | 13% |
Student > Master | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Other | 4 | 8% |
Unknown | 14 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 29% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 13% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Nursing and Health Professions | 3 | 6% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 5 | 10% |
Unknown | 14 | 29% |