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Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression

Overview of attention for article published in Psychoneuroendocrinology, January 2014
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Title
Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression
Published in
Psychoneuroendocrinology, January 2014
DOI 10.1016/j.psyneuen.2014.01.012
Pubmed ID
Authors

Sarah M. Thompson, Constance Hammen, Lisa R. Starr, Jake M. Najman

Abstract

Maternal depression serves as a potent source of stress among offspring, greatly enhancing the risk of numerous adverse outcomes including youth depression. Several factors moderate the transmission of depression from mothers to offspring. However, the role of genetic characteristics in this process merits further exploration. Consistent with an interpersonal perspective on depression, the present study focused on a genetic polymorphism that has been shown to be relevant to social functioning, the rs53576 polymorphism of the oxytocin receptor gene (OXTR). In a community sample of 441 youth, OXTR genotype moderated the association between maternal depression in early childhood and youth depressive symptoms in adolescence, such that youth possessing at least one A allele of OXTR who also had a history of maternal depression exhibited the highest levels of depressive symptoms at age 15. In order to explore possible interpersonal mediators of this effect, conditional process analyses examined the role of youth social functioning in adolescence. Results suggest that OXTR genotype may partially account for the transmission of maternal depression to youth and support the role of dysfunctional social processes as a mechanism through which OXTR influences the development of depressive symptoms.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Hungary 1 <1%
Portugal 1 <1%
Canada 1 <1%
Unknown 113 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 16%
Student > Ph. D. Student 18 15%
Student > Doctoral Student 15 13%
Student > Bachelor 12 10%
Student > Master 11 9%
Other 24 21%
Unknown 18 15%
Readers by discipline Count As %
Psychology 42 36%
Medicine and Dentistry 14 12%
Neuroscience 11 9%
Agricultural and Biological Sciences 7 6%
Biochemistry, Genetics and Molecular Biology 6 5%
Other 15 13%
Unknown 22 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2018.
All research outputs
#16,047,334
of 25,374,647 outputs
Outputs from Psychoneuroendocrinology
#2,610
of 3,904 outputs
Outputs of similar age
#187,128
of 322,830 outputs
Outputs of similar age from Psychoneuroendocrinology
#25
of 44 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,830 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.