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EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Overview of attention for article published in Nature Communications, June 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

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Title
EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
Published in
Nature Communications, June 2017
DOI 10.1038/ncomms15773
Pubmed ID
Authors

Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis, Heide L. Ford

Abstract

Recent fate-mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that these studies failed to account for possible crosstalk between EMT and non-EMT cells that promotes dissemination of non-EMT cells. In breast cancer models, EMT cells induce increased metastasis of weakly metastatic, non-EMT tumour cells in a paracrine manner, in part by non-cell autonomous activation of the GLI transcription factor. Treatment with GANT61, a GLI1/2 inhibitor, but not with IPI 926, a Smoothened inhibitor, blocks this effect and inhibits growth in PDX models. In human breast tumours, the EMT-transcription factors strongly correlate with activated Hedgehog/GLI signalling but not with the Hh ligands. Our findings indicate that EMT contributes to metastasis via non-cell autonomous effects that activate the Hh pathway. Although all Hh inhibitors may act against tumours with canonical Hh/GLI signalling, only GLI inhibitors would act against non-canonical EMT-induced GLI activation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 113 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 24%
Researcher 16 14%
Student > Bachelor 12 11%
Student > Master 7 6%
Student > Postgraduate 6 5%
Other 16 14%
Unknown 29 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 38 34%
Agricultural and Biological Sciences 14 12%
Medicine and Dentistry 11 10%
Immunology and Microbiology 5 4%
Engineering 4 4%
Other 7 6%
Unknown 34 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 491. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2019.
All research outputs
#43,696
of 22,979,862 outputs
Outputs from Nature Communications
#675
of 47,291 outputs
Outputs of similar age
#1,015
of 317,409 outputs
Outputs of similar age from Nature Communications
#16
of 1,111 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,291 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,409 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,111 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.