| Title |
Zika Virus as an Emerging Neuropathogen: Mechanisms of Neurovirulence and Neuro-Immune Interactions
|
|---|---|
| Published in |
Molecular Neurobiology, June 2017
|
| DOI | 10.1007/s12035-017-0635-y |
| Pubmed ID | |
| Authors |
Gerwyn Morris, Tatiana Barichello, Brendon Stubbs, Cristiano A. Köhler, André F. Carvalho, Michael Maes |
| Abstract |
Zika virus (ZIKV) is an emerging arbovirus of the genus Flaviviridae, which causes a febrile illness and has spread from across the Pacific to the Americas in a short timeframe. Convincing evidence has implicated the ZIKV to incident cases of neonatal microcephaly and a set of neurodevelopmental abnormalities referred to as the congenital Zika virus syndrome. In addition, emerging data points to an association with the ZIKV and the development of the so-called Guillain-Barre syndrome, an acute autoimmune polyneuropathy. Accumulating knowledge suggests that neurovirulent strains of the ZIKV have evolved from less pathogenic lineages of the virus. Nevertheless, mechanisms of neurovirulence and host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion of genetic and structural alterations in the ZIKV which could have contributed to the emergence of neurovirulent strains. In addition, a mechanistic framework of neuro-immune mechanisms related to the emergence of neuropathology after ZIKV infection is discussed. Recent advances in knowledge point to avenues for the development of a putative vaccine as well as novel therapeutic strategies. Nevertheless, there are unique unmet challenges that need to be addressed in this regard. Finally, a research agenda is proposed. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 26 | 19% |
| Student > Master | 25 | 18% |
| Researcher | 13 | 9% |
| Student > Ph. D. Student | 13 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 24 | 17% |
| Unknown | 30 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 17% |
| Biochemistry, Genetics and Molecular Biology | 20 | 14% |
| Immunology and Microbiology | 13 | 9% |
| Agricultural and Biological Sciences | 10 | 7% |
| Nursing and Health Professions | 7 | 5% |
| Other | 26 | 19% |
| Unknown | 38 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2019.
All research outputs
#15,464,404
of 22,979,862 outputs
Outputs from Molecular Neurobiology
#2,075
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Outputs of similar age
#199,248
of 317,392 outputs
Outputs of similar age from Molecular Neurobiology
#65
of 128 outputs
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