| Title |
Vitamin D Deficiency and its Role in Muscle-Bone Interactions in the Elderly
|
|---|---|
| Published in |
Current Osteoporosis Reports, February 2014
|
| DOI | 10.1007/s11914-014-0193-4 |
| Pubmed ID | |
| Authors |
Kerrie M. Sanders, David Scott, Peter R. Ebeling |
| Abstract |
In this commentary, we focus on common 'downstream' links of vitamin D between muscle and bone health. Both direct and indirect effects of 1,25 dihydroxyvitamin D (1,25(OH)D) link the mutual age-related decline in muscle function and bone density, independent of physical activity. Changes in calcium absorption associated with vitamin D deficiency affect both muscle and bone mass. The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -α and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues. Controversial findings on the role of 1,25(OH)D on skeletal muscle may relate to differences in vitamin D receptor expression throughout different stages of muscle cell differentiation. Prolonged vitamin D insufficiency in the elderly is associated with reductions in both bone mineral density and type 2 muscle fibers with the outcomes of skeletal fragility in combination with reduced muscle power, leading to increased risk of falls and fracture. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 147 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 25 | 17% |
| Student > Bachelor | 21 | 14% |
| Student > Ph. D. Student | 16 | 11% |
| Researcher | 11 | 7% |
| Student > Doctoral Student | 11 | 7% |
| Other | 28 | 19% |
| Unknown | 37 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 47 | 32% |
| Agricultural and Biological Sciences | 13 | 9% |
| Nursing and Health Professions | 11 | 7% |
| Sports and Recreations | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 20 | 13% |
| Unknown | 47 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2020.
All research outputs
#905,546
of 22,743,667 outputs
Outputs from Current Osteoporosis Reports
#12
of 545 outputs
Outputs of similar age
#10,996
of 307,251 outputs
Outputs of similar age from Current Osteoporosis Reports
#2
of 12 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 545 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.