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Mendeley readers
Attention Score in Context
| Title |
The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults
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|---|---|
| Published in |
Neuropsychopharmacology, June 2017
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| DOI | 10.1038/npp.2017.121 |
| Pubmed ID | |
| Authors |
Hengyi Cao, Anais Harneit, Henrik Walter, Susanne Erk, Urs Braun, Carolin Moessnang, Lena S Geiger, Zhenxiang Zang, Sebastian Mohnke, Andreas Heinz, Nina Romanczuk-Seiferth, Thomas Mühleisen, Manuel Mattheisen, Stephanie H Witt, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Andreas Meyer-Lindenberg, Heike Tost |
| Abstract |
The serotonin transporter linked polymorphic region 5-HTTLPR is a key genetic regulator of 5-HTT expression in the human brain where the short allele S has been implicated in emotion dysregulation. However, the neural mechanism underlying the association between this variant and emotion processing is still unclear. Earlier studies suggested an effect of 5-HTTLPR on amygdala activation during emotional face processing. However, this association has been questioned in recent studies employing larger sample sizes and meta-analyses. Here, we examined a sample of 223 healthy subjects with a well-established fMRI emotional face processing task to (1) reevaluate the association between 5-HTTLPR and amygdala activation, (2) explore potential network-based functional connectivity phenotypes for associations with 5-HTTLPR, and (3) probe the reliability, behavioral significance and potential structural confounds of the identified network phenotype. Our results revealed no significant effect of 5-HTTLPR on amygdala activation (P>0.79). However, the number of S allele was significantly correlated with functional connectivity of a visual-limbic subnetwork (PFWE=0.03). The subnetwork cluster included brain regions that are pivotal to emotion regulation such as the hippocampus, orbitofrontal cortex, anterior cingulate gyrus, fusiform gyrus and subcortex. Notably, individuals with lower subnetwork connectivity had significantly higher emotion suppression scores (P=0.01). Further, the connectivity metrics were test-retest reliable and independent from subnetwork gray matter volume and white matter anisotropy. Our data provide evidence for a functional network-based phenotype linking genetic variation in 5-HTTLPR to emotion regulation, and suggest that further critical evaluations of the association between 5-HTTLPR and amygdala activation are warranted.Neuropsychopharmacology accepted article preview online, 07 June 2017. doi:10.1038/npp.2017.121. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Germany | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 44% |
| Scientists | 3 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 56 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 18% |
| Student > Bachelor | 7 | 12% |
| Student > Ph. D. Student | 6 | 11% |
| Student > Doctoral Student | 5 | 9% |
| Student > Master | 4 | 7% |
| Other | 12 | 21% |
| Unknown | 13 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 21% |
| Neuroscience | 11 | 19% |
| Medicine and Dentistry | 7 | 12% |
| Agricultural and Biological Sciences | 2 | 4% |
| Business, Management and Accounting | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 18 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2017.
All research outputs
#6,957,815
of 24,857,051 outputs
Outputs from Neuropsychopharmacology
#2,591
of 4,387 outputs
Outputs of similar age
#103,690
of 322,556 outputs
Outputs of similar age from Neuropsychopharmacology
#55
of 69 outputs
Altmetric has tracked 24,857,051 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,387 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,556 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.