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A Hard-Wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila

Overview of attention for article published in Neuron, February 2014
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  • Good Attention Score compared to outputs of the same age (70th percentile)

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Title
A Hard-Wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila
Published in
Neuron, February 2014
DOI 10.1016/j.neuron.2013.12.010
Pubmed ID
Authors

Thangavel Karuppudurai, Tzu-Yang Lin, Chun-Yuan Ting, Randall Pursley, Krishna V. Melnattur, Fengqiu Diao, Benjamin H. White, Lindsey J. Macpherson, Marco Gallio, Thomas Pohida, Chi-Hon Lee

Abstract

Many visual animals have innate preferences for particular wavelengths of light, which can be modified by learning. Drosophila's preference for UV over visible light requires UV-sensing R7 photoreceptors and specific wide-field amacrine neurons called Dm8. Here we identify three types of medulla projection neurons downstream of R7 and Dm8 and show that selectively inactivating one of them (Tm5c) abolishes UV preference. Using a modified GRASP method to probe synaptic connections at the single-cell level, we reveal that each Dm8 neuron forms multiple synaptic contacts with Tm5c in the center of Dm8's dendritic field but sparse connections in the periphery. By single-cell transcript profiling and RNAi-mediated knockdown, we determine that Tm5c uses the kainate receptor Clumsy to receive excitatory glutamate input from Dm8. We conclude that R7s→Dm8→Tm5c form a hard-wired glutamatergic circuit that mediates UV preference by pooling ∼16 R7 signals for transfer to the lobula, a higher visual center.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 3%
Portugal 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
Austria 1 <1%
Spain 1 <1%
Argentina 1 <1%
Unknown 187 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 27%
Researcher 50 25%
Student > Master 20 10%
Student > Bachelor 19 10%
Student > Doctoral Student 11 6%
Other 21 11%
Unknown 24 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 87 44%
Neuroscience 58 29%
Biochemistry, Genetics and Molecular Biology 11 6%
Environmental Science 4 2%
Computer Science 2 1%
Other 11 6%
Unknown 26 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2020.
All research outputs
#8,261,756
of 25,373,627 outputs
Outputs from Neuron
#6,493
of 9,543 outputs
Outputs of similar age
#93,558
of 322,718 outputs
Outputs of similar age from Neuron
#88
of 115 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 9,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.