| Title |
Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice
|
|---|---|
| Published in |
Diabetologia, June 2013
|
| DOI | 10.1007/s00125-013-2957-2 |
| Pubmed ID | |
| Authors |
J. H. Ellenbroek, H. A. M. Töns, M. J. A. Westerouen van Meeteren, N. de Graaf, M. A. Hanegraaf, T. J. Rabelink, F. Carlotti, E. J. P. de Koning |
| Abstract |
Incretin-based therapies improve glycaemic control in patients with type 2 diabetes. In animal models of diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) increase beta cell mass. GLP-1RAs are also evaluated in non-diabetic individuals with obesity and cardiovascular disease. However, their effect on beta cell mass in normoglycaemic conditions is not clear. Here, we investigate the effects of the GLP-1RA liraglutide on beta cell mass and function in normoglycaemic mice. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Netherlands | 1 | 2% |
| Denmark | 1 | 2% |
| Unknown | 48 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 25% |
| Student > Ph. D. Student | 12 | 24% |
| Student > Bachelor | 6 | 12% |
| Student > Postgraduate | 4 | 8% |
| Student > Master | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 39% |
| Agricultural and Biological Sciences | 13 | 25% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Neuroscience | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 6 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2014.
All research outputs
#20,219,902
of 22,743,667 outputs
Outputs from Diabetologia
#4,877
of 5,033 outputs
Outputs of similar age
#155,802
of 178,152 outputs
Outputs of similar age from Diabetologia
#43
of 44 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.