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Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal–Maternal Interface and the Peripheral Blood

Overview of attention for article published in Frontiers in immunology, January 2014
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Title
Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal–Maternal Interface and the Peripheral Blood
Published in
Frontiers in immunology, January 2014
DOI 10.3389/fimmu.2014.00033
Pubmed ID
Authors

Michelle A. Neller, Brigitte Santner-Nanan, Rebekah M. Brennan, Peter Hsu, Steven Joung, Ralph Nanan, Scott R. Burrows, John J. Miles

Abstract

The human T cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known about repertoire composition at different anatomical sites. Here, we determine the T cell receptor beta variable (TRBV) repertoire at the decidua and compare it with the peripheral blood during normal pregnancy and pre-eclampsia. We found total T cell subset disparity of up to 58% between sites, including large signature TRBV expansions unique to the fetal-maternal interface. Defining the functional nature and specificity of compartment-specific T cells will be necessary if we are to understand localized immunity, tolerance, and pathogenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 29%
Student > Master 5 21%
Researcher 4 17%
Student > Doctoral Student 3 13%
Student > Bachelor 2 8%
Other 2 8%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 33%
Immunology and Microbiology 5 21%
Medicine and Dentistry 5 21%
Biochemistry, Genetics and Molecular Biology 2 8%
Computer Science 1 4%
Other 2 8%
Unknown 1 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2014.
All research outputs
#16,737,737
of 25,394,764 outputs
Outputs from Frontiers in immunology
#18,354
of 31,554 outputs
Outputs of similar age
#196,287
of 319,416 outputs
Outputs of similar age from Frontiers in immunology
#46
of 97 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,416 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.