| Title |
Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate
|
|---|---|
| Published in |
Comparative Haematology International, October 2013
|
| DOI | 10.1007/s00580-013-1818-1 |
| Pubmed ID | |
| Authors |
Emmanuel Vandi Tizhe, Najume Dogon-Giginya Ibrahim, Mohammed Yakasai Fatihu, Igbokwe Ikechukwu Onyebuchi, Butcher Danladi Jonathan George, Suleiman Folorunsho Ambali, Joshua Mallum Shallangwa |
| Abstract |
A subchronic toxicity study was carried out to determine the glyphosate-induced histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen of rats and the attendant ameliorative effect when pretreated with zinc at the dose rate of 50 mg/kg body weight. The rats were exposed to two doses of the glyphosate (375 and 14.4 mg/kg body weight) for the period of 8 weeks which was the duration of the study, and some groups were exposed to the glyphosate after pretreatment with zinc. The histopathological changes recorded during the study were only in the rats exposed to the glyphosate at the dose rate of 375 mg/kg body weight except the vacuolation encountered in the brains and haemosiderosis in the spleens of rats exposed to zinc alone. Degenerated mucosal epithelial cells which involved the muscularis mucosa and the glands in the stomachs of rats were seen microscopically. Hepatic cells degeneration especially at the portal areas of the livers of rats was observed. The histopathological examination of the kidneys showed glomerular degeneration, mononuclear cells infiltration into the interstices of the tubules and tubular necrosis. The conspicuous changes seen in the brains were neuronal degeneration. Pancreatic acinar cells were degenerated while the spleen of the rats showed depopulated splenic cells in both the red and the white pulps. It was concluded that zinc supplementation in rats prior to glyphosate exposure ameliorated the histopathological changes observed in the stomach, liver, kidney, brain, pancreas and spleen with no observable alteration in the histoarchitecture in the organs of the zinc-supplemented rats. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 25% |
| Canada | 1 | 5% |
| Japan | 1 | 5% |
| Mexico | 1 | 5% |
| Spain | 1 | 5% |
| Unknown | 11 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 85% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 15% |
| Researcher | 6 | 11% |
| Student > Doctoral Student | 5 | 9% |
| Student > Bachelor | 4 | 7% |
| Professor | 4 | 7% |
| Other | 8 | 15% |
| Unknown | 19 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 22% |
| Medicine and Dentistry | 9 | 17% |
| Veterinary Science and Veterinary Medicine | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Neuroscience | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 20 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2024.
All research outputs
#2,411,400
of 25,715,849 outputs
Outputs from Comparative Haematology International
#3
of 422 outputs
Outputs of similar age
#21,429
of 223,692 outputs
Outputs of similar age from Comparative Haematology International
#1
of 3 outputs
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So far Altmetric has tracked 422 research outputs from this source. They receive a mean Attention Score of 1.5. This one has done particularly well, scoring higher than 99% of its peers.
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