Title |
Cytotoxic Spiroepoxide Lactone and Its Putative Biosynthetic Precursor from Goniobranchus Splendidus
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Published in |
ACS Omega, June 2017
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DOI | 10.1021/acsomega.7b00641 |
Pubmed ID | |
Authors |
Louise C. Forster, Gregory K. Pierens, Andrew M. White, Karen L. Cheney, Pradeep Dewapriya, Robert J. Capon, Mary J. Garson |
Abstract |
Epoxygoniolide-1 (1), possessing spiroepoxide lactone, enal, and masked dialdehyde functionalities, has been characterized from the conspicuously patterned mollusc Goniobranchus splendidus. Its relative configuration was investigated by spectroscopic analyses, molecular modeling, and density functional theory calculations. The biosynthesis of 1 may involve rearrangement of a diterpene framework, providing a precursor to cometabolite gonioline (2), followed by C-C bond cleavage (via Grob or P450 mechanism). Moderate cytotoxicity to NCIH-460, SW60, or HepG2 cancer cells was observed for norditerpene 1. |
X Demographics
Geographical breakdown
Country | Count | As % |
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New Zealand | 1 | 33% |
Australia | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 33% |
Student > Ph. D. Student | 1 | 17% |
Professor > Associate Professor | 1 | 17% |
Student > Postgraduate | 1 | 17% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 33% |
Chemistry | 2 | 33% |
Unknown | 2 | 33% |