| Title |
Novel Genetic and Molecular Tools for the Investigation and Control of Dengue Virus Transmission by Mosquitoes
|
|---|---|
| Published in |
Current Tropical Medicine Reports, January 2014
|
| DOI | 10.1007/s40475-013-0007-2 |
| Pubmed ID | |
| Authors |
Alexander W. E. Franz, Rollie J. Clem, A. Lorena Passarelli |
| Abstract |
Aedes aegypti is the principal vector of dengue virus (DENV) throughout the tropical world. This anthropophilic mosquito species needs to be persistently infected with DENV before it can transmit the virus through its saliva to a new vertebrate host. In the mosquito, DENV is confronted with several innate immune pathways, among which RNA interference is considered the most important. The Ae. aegypti genome project opened the doors for advanced molecular studies on pathogen-vector interactions including genetic manipulation of the vector for basic research and vector control purposes. Thus, Ae. aegypti has become the primary model for studying vector competence for arboviruses at the molecular level. Here, we present recent findings regarding DENV-mosquito interactions, emphasizing how innate immune responses modulate DENV infections in Ae. aegypti. We also describe the latest advancements in genetic manipulation of Ae. aegypti and discuss how this technology can be used to investigate vector transmission of DENV at the molecular level and to control transmission of the virus in the field. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 5% |
| Portugal | 1 | 1% |
| Brazil | 1 | 1% |
| Malaysia | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 70 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 28% |
| Student > Master | 16 | 20% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Bachelor | 6 | 8% |
| Student > Postgraduate | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 44% |
| Medicine and Dentistry | 11 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Social Sciences | 4 | 5% |
| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 10 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2014.
All research outputs
#18,363,356
of 22,743,667 outputs
Outputs from Current Tropical Medicine Reports
#106
of 134 outputs
Outputs of similar age
#228,912
of 304,971 outputs
Outputs of similar age from Current Tropical Medicine Reports
#4
of 6 outputs
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